![]() This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Acne is a multifactorial disease of the pilosebaceous unit. Ĭarrier-Based Drug Delivery System for Treatment of AcneĪpproximately 95% of the population suffers at some point in their lifetime from acne vulgaris. ![]() ACOG) recommends topical benzoyl peroxide, azelaic acid, topical salicylic acid and glycolic acid for treatment of acne in. Prescription acne medications include tretinoin, adapalene, dapsone, and. are benzoyl peroxide, azelaic acid, glycolic acid, and salicylic acid. Advanced formulations and combination formulations of benzoyl peroxide, clindamycin, and tretinoin will also be discussed. This article will review the goals of topical therapy for the treatment of acne, in addition to common therapies and their challenges. Novel formulations that optimize drug concentration and utilize improved delivery vehicles have helped to enhance the tolerability and efficacy, and allow for less frequent application or co-application of drugs that were previously considered incompatible. Thus, choosing the right formulation that will be effective and well tolerated is essential. Despite their effectiveness in treating mild to moderate acne vulgaris, these topical medications are found to be irritating, and are historically associated with poor tolerability and diminished patient adherence. ![]() The most commonly prescribed topical medications for acne include benzoyl peroxide, clindamycin, and retinoids. Topical treatment is the mainstay of acne therapy. Hoffman, Lauren K Bhatia, Neal Zeichner, Joshua Kircik, Leon H Topical Vehicle Formulations in the Treatment of Acne. ![]()
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January 2023
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